Adderall XR 30mg (Extended-Release Capsules)

Adderall XR 30mg is widely known for its use in treating ADHD (Attention Deficit Hyperactivity Disorder). But is Adderall XR 30mg effective? What are the dosage and usage instructions? Please read on to learn more about this product below.

What is Adderall XR 30mg?

Adderall XR 30mg is a prescription medication that stimulates the central nervous system and is commonly used to treat attention deficit hyperactivity disorder (ADHD) in adults and children over 6 years of age. It is manufactured by Shire USA Inc. of the United States and is currently available in the Vietnamese market.

Ingredient

Each Adderall XR 30mg extended-release capsule  contains the following active ingredients:

Amphetamine 30mg

In addition, it contains other excipients in sufficient quantities.

Effects of Adderall XR

• Amphetamine is a central nervous system (CNS) stimulant that acts by increasing dopamine, norepinephrine, and serotonin through various mechanisms.
• Amphetamines reach the presynaptic axon terminal through diffusion or absorption by monoamine transporters DAT, NET, and SERT. Once at the presynaptic terminal, amphetamines increase monoamine neurotransmitters by inhibiting the monoamine transporter VMAT2 and disrupting the electrochemical gradient.
• Amphetamine also inhibits the metabolism of monoamine neurotransmitters by inhibiting MAO (monoamine oxidase). Simultaneously, it stimulates intracellular TAAR1 receptors and extends to NET and SERT receptors. This increases the dopamine flow to the synaptic clefts, leading to inhibition of reuptake and direct competition.

Uses and indications of Adderall XR 30mg

Adderall XR 30mg is commonly used in the following cases:

Attention deficit hyperactivity disorder (ADHD) and narcolepsy in adults and pediatric patients aged 6 years and older.

Adderall XR 30mg is a medication used to treat attention deficit hyperactivity disorder (ADHD).

Pharmacokinetics

Absorption

The drug is well absorbed in the intestines, with the strongest effect occurring approximately 1-3 hours after oral administration and about 15 minutes after injection. Bioavailability is over 75%, and complete absorption occurs after about 4-6 hours. The effect lasts from 4-24 hours after oral administration.

Distribution

The volume of distribution of the drug is approximately 4 L/kg.

Metabolism

Amphetamine is primarily metabolized in the liver via CYP2D6, with the main metabolic pathways being fatty hydroxylation, aromatic hydroxylation, and n-dealkyl dehydrogenation, producing metabolites such as hippuric acid, 4-hydroxynor ephedrine , benzyl methyl ketone, benzoic acid, and p-hydroxyamphetamine. These metabolites all produce strong hallucinations .

Eliminate

The half-life of amphetamine depends primarily on its isomer; for the D isomer, the half-life is approximately 9-11 hours, and for the L isomer, the half-life is approximately 11-14 hours.

Dosage and administration of Adderall XR 30mg

Dosage

Children aged 6-12:

• In pediatric patients aged 6 to 12 years with ADHD who are starting treatment for the first time or switching from another medication, begin with 10 mg once daily in the morning.
• The daily dose may be adjusted in increments of 5 mg or 10 mg per week.
• The maximum recommended dose for children aged 6 to 12 years is 30 mg/day; doses greater than 30 mg/day have not been studied in children.
• Adderall XR 30mg has not been studied in children under 6 years of age.

Children aged 13-17:

• The recommended starting dose for pediatric patients aged 13-17 years with ADHD who are starting treatment for the first time or switching from another medication is 10 mg/day.
• The dose may be increased to 20 mg/day after one week if ADHD symptoms are not controlled.

Adult:

• For adults with ADHD who are starting treatment for the first time or switching from another medication, the recommended dose is 20 mg/day.

Kidney failure:

• Because amphetamine clearance is reduced in patients with severe renal impairment (GFR 15 to <30 mL/min/1.73 m2), the recommended dose should be reduced to 15 mg once daily in the morning.
• For pediatric patients aged 6-17 years with severe renal impairment, the recommended dose is 5 mg once daily. The maximum dose for children aged 6-12 years with severe renal impairment is 20 mg once daily.
• Not recommended for use in patients with ESRD (GFR <15 mL/min/1.73 m² ) .

Use

It can be taken with or without food, but it's best to take it in the morning.

Contraindications

Adderall XR 30mg should not be used in the following cases:

• Hypersensitivity to amphetamine or other components of the drug.
• Currently taking MAOIs or within 14 days of stopping MAOIs.

Side effects

The following side effects may occur after taking Adderall XR 30mg:

• Allergic reactions:  Urticaria, rash, hypersensitivity reactions including angioedema and anaphylactic shock. Severe skin rashes, including Stevens-Johnson syndrome and toxic epidermal necrosis, have been reported.
• Cardiovascular:  Palpitations . There have been isolated reports of cardiomyopathy associated with chronic amphetamine use.
• Central nervous system:  Psychotic episodes at recommended doses, hyperstimulation, restlessness, irritability, euphoria, dyskinesia, agitation, depression, tremor, motor and speech twitching, aggression, anger , drooling, dermatological mania, paresthesia (including teeth-clenching behavior) and bruxism.
• Hormonal:  Impotence, changes in libido, frequent or prolonged erections.
• Eye disorders:  Blurred vision, dilated pupils.
• Digestive system:  Anorexia, constipation , intestinal ischemia, and other digestive disorders.
• Musculoskeletal and connective tissue disorders : Rhabdomyolysis.
• Skin:  Hair loss .
• Vascular disorders:  Raynaud's phenomenon.

Drug interactions

Notes on using and storing medication

Note and caution

• Before prescribing medication, it is necessary to assess the risk of abuse, misuse, and potential for addiction in each patient.
• Educate patients and their families about the risks involved, as well as how to properly store and dispose of medications.
• It is necessary to monitor and assess the risk of signs and symptoms of drug abuse and addiction.
• Note that the misuse of central nervous system stimulants can lead to overdose and death.
• Avoid using this medication in patients with cardiomyopathy, arrhythmias, or coronary artery disease.
• Monitor blood pressure and heart rate during treatment.
• Monitor the height and weight of pediatric patients; if they are not developing normally, consider discontinuing medication and choosing an alternative therapy.
• Stop using the medication if you have a seizure.
• Careful clinical evaluation of patients with signs of peripheral vascular disease such as Raynaud's syndrome is essential .
• Treatment may be stopped if Tourette syndrome worsens.

Note for pregnant and breastfeeding women

For pregnant women: it may cause premature birth and low birth weight in infants when used during pregnancy. Use only after careful consideration of the benefits and risks by a doctor.

For breastfeeding women: it may inhibit milk production, therefore breastfeeding is not recommended while undergoing treatment with this medication.

Note for drivers and machine operators

Use caution when administering this medication to drivers and those operating machinery.

Preserve

Store in a dry place, at a temperature below 30 degrees Celsius.

Management of overdose and missed doses of medication.

Overdose

Symptom:

• Cardiovascular effects include tachycardia and hypertension or hypotension. Vasospasm, myocardial infarction , or aortic dissection can lead to sudden cardiac death. Takotsubo cardiomyopathy may occur.
• Effects on the central nervous system include psychomotor agitation, confusion, and hallucinations. Serotonin syndrome, seizures , stroke, and coma may also occur .
• Hyperthermia can be life-threatening (temperatures greater than 104°F) and can cause rhabdomyolysis.

How to handle it:

Treatment should be symptomatic and supportive. Amphetamines are not removed by hemodialysis.

Missed dose

Avoid missing doses. If you miss a dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose.

Is Adderall XR 30mg a good medication?

Advantage

• The medication is formulated as extended-release capsules, so the concentration of the drug released into the body is tightly controlled and pre-calculated. In addition, it reduces the number of doses needed, requiring only one capsule per day.
• New drugs, recently invented, are improvements over previous forms of medication.
• The medicine is imported from Shire US Inc. in the United States, which is one of the world's leading pharmaceutical experts.
• Adderall XR 30mg has been approved by the FDA (U.S. Food and Drug Administration) for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.

Disadvantages

• Abuse can easily lead to addiction, and an overdose can be fatal; therefore, close monitoring by a doctor is necessary.

How much does Adderall XR 30mg cost?

How much does Adderall XR 30mg cost? The price of the medication is being updated continuously to meet customer demand. Please contact us directly via our fanpage for any questions.

Where can I buy genuine Adderall XR 30mg?

Adderall XR 30mg is a new medication imported from the United States and is not yet widely available in the Vietnamese market. To purchase genuine products, you need to buy from reputable pharmacies. You can visit the website discreetpeople.com or message the Ngoc Anh Pharmacy fanpage for more detailed product information.